Kurt Brunden: search on Z-Library

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1

Therapeutic strategies for the treatment of tauopathies: Hopes and challenges

Khanna, Mansi R., Kovalevich, Jane, Lee, Virginia M.-Y., Trojanowski, John Q., Brunden, Kurt R.

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 551 KB

english, 2016

2

Correction of microtubule defects within AÎ² plaque-associated dystrophic axons results in lowered AÎ² release and plaque deposition

Yao, Yuemang, Nzou, Goodwell, Alle, Thibault, Tsering, Wangchen, Maimaiti, Shaniya, Trojanowski, John Q., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.

Journal:

Alzheimer's & Dementia

Year:

2020

File:

PDF, 1.48 MB

2020

3

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y.

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 717 KB

english, 2009

4

Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro

Monti, Ludovica, Cornec, Anne-Sophie, Oukoloff, Killian, Kovalevich, Jane, Prijs, Kristen, Alle, Thibault, Brunden, Kurt R., Smith, Amos B., El-Sakkary, Nelly, Liu, Lawrence J., Syed, Ali, Skinner, Da

Journal:

ACS Infectious Diseases

Year:

2020

File:

PDF, 2.64 MB

2020

5

1,2,4-Triazolo[1,5-a]pyrimidines in drug design

Oukoloff, Killian, Lucero, Bobby, Francisco, Karol R., Brunden, Kurt R., Ballatore, Carlo

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.78 MB

english, 2019

6

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors

Kurt R. Brunden, Carlo Ballatore, Alex Crowe, Amos B. Smith, III, Virginia M.-Y. Lee, John Q. Trojanowski

Journal:

Experimental Neurology

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

7

Structure Property Relationships of Carboxylic Acid Isosteres

Lassalas, Pierrik, Gay, Bryant, Lasfargeas, Caroline, James, Michael J, Tran, Van, Vijayendran, Krishna G, Brunden, Kurt R, Kozlowski, Marisa C, Thomas, Craig J, Smith III, Amos B, Huryn, Donna M., Ba

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

8

Congo Red Inhibits Proteoglycan and Serum Amyloid P Binding to Amyloid β Fibrils

Rekha Gupta-Bansal, Kurt R. Brunden

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 734 KB

english, 1998

9

Deposits of Aβ fibrils are not toxic to cortical and hippocampal neurons in vitro

Jerome R. Wujek, Michael D. Dority, Robert C.A. Frederickson, Kurt R. Brunden

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 689 KB

english, 1996

10

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine

Cornec, Anne-Sophie, James, Michael J., Kovalevich, Jane, Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B., Ballatore, Carlo, Brunden, Kurt R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 854 KB

english, 2015

11

Investigation of 4-piperidinols as novel H3 antagonists

James T. Anderson, Michael Campbell, Jianmin Wang, Kurt R. Brunden, John J. Harrington, Alain Stricker-Krongrad, Jianping Song, Chris Doucette, Steven Murphy, Youssef L. Bennani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 425 KB

english, 2010

12

Studies on the mechanism of action of channel-forming colicins using artificial membranes

Victor L. Davidson, Kurt R. Brunden, William A. Cramer, Fredric S. Cohen

Journal:

Journal of Membrane Biology

Year:

1984

Language:

english

File:

PDF, 1.17 MB

english, 1984

13

Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel

Steven M. Murphy, Marc Palmer, Michelle Fontilla Poole, Linas Padegimas, Karen Hunady, Joel Danzig, Sikander Gill, Rajwant Gill, Anthony Ting, Bruce Sherf, Kurt Brunden, Alain Stricker-Krongrad

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2006

Language:

english

File:

PDF, 235 KB

english, 2006

14

Characterization of tau fibrillization in vitro

Shaohua Xu, Kurt R. Brunden, John Q. Trojanowski, Virginia M.-Y. Lee

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 918 KB

english, 2010

15

Kinetics of production of a novel growth factor after peripheral nerve injury

Marceil D. Blexrud, Deborah A. Lee, Anthony J. Windebank, Kurt R. Brunden

Journal:

Journal of the Neurological Sciences

Year:

1990

Language:

english

File:

PDF, 930 KB

english, 1990

16

Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches

Suio Chen, Robert C.A. Frederickson, Kurt R. Brunden

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 642 KB

english, 1996

17

The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist

Bayard R. Huck, Luis Llamas, Michael J. Robarge, Thomas C. Dent, Jianping Song, William F. Hodnick, Chris Crumrine, Alain Stricker-Krongrad, John Harrington, Kurt R. Brunden, Youssef L. Bennani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

18

A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research

John Q. Trojanowski, Steven E. Arnold, Jason H. Karlawish, Mary Naylor, Kurt R. Brunden, Virginia M.-Y. Lee

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 602 KB

english, 2012

19

MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications

Brunden, Kurt R., Gardner, Nicola M., James, Michael J., Yao, Yuemang, Trojanowski, John Q., Lee, Virginia M.-Y., Paterson, Ian, Ballatore, Carlo, Smith, Amos B.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 455 KB

english, 2013

20

Discovery of S-Phase Arresting Agents Derived from Noscapine

Anderson, James T., Ting, Anthony E., Boozer, Sherry, Brunden, Kurt R., Danzig, Joel, Dent, Tom, Harrington, John J., Murphy, Steven M., Perry, Rob, Raber, Amy, Rundlett, Stephen E., Wang, Jianmin, Wa

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 90 KB

english, 2005

21

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

Brunden, Kurt R., Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 829 KB

english, 2014

22

The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors

L. Nathan Tumey, Bayard Huck, Elizabeth Gleason, Jianmin Wang, Daniel Silver, Kurt Brunden, Sherry Boozer, Stephen Rundlett, Bruce Sherf, Steven Murphy, Andrew Bailey, Tom Dent, Christina Leventhal, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

23

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group

Ballatore, Carlo, Gay, Bryant, Huang, Longchuan, Robinson, Katie Herbst, James, Michael J., Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R., Smith, Amos B.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

24

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

Ballatore, Carlo, Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 456 KB

english, 2017

25

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

Oukoloff, Killian, Kovalevich, Jane, Cornec, Anne-Sophie, Yao, Yuemang, Owyang, Zachary A., James, Michael, Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B., Brunden, Kurt R., Ballatore, Carl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 206 KB

english, 2018

26

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

Zhang, Bin, Yao, Yuemang, Cornec, Anne-Sophie, Oukoloff, Killian, James, Michael J., Koivula, Pyry, Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.

Journal:

Molecular Neurodegeneration

Year:

2018

Language:

english

File:

PDF, 1.40 MB

english, 2018

27

Design of comprehensive Alzheimer's disease centers to address unmet national needs

John Q. Trojanowski, Steven E. Arnold, Jason H. Karlawish, Kurt Brunden, Mark Cary, Christos Davatzikos, John Detre, Glen Gaulton, Murray Grossman, Howard Hurtig, Kathryn Jedrziewski, Leo McCluskey, M

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 592 KB

english, 2010

28

Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497

Ballatore, Carlo, Smith, Amos B, Lee, Virginia M-Y, Trojanowski, John Q, Brunden, Kurt R

Journal:

Expert Opinion on Therapeutic Patents

Year:

2014

Language:

english

File:

PDF, 694 KB

english, 2014

29

Isolation of an integral membrane glycoprotein by chloroform-methanol extraction and C3-reversed-phase high-performance liquid chromatography

Kurt R. Brunden, Carole T. Berg, Joseph F. Poduslo

Journal:

Analytical Biochemistry

Year:

1987

Language:

english

File:

PDF, 1.41 MB

english, 1987

30

Brain-Penetrant Tetrahydronaphthalene Thromboxane A2-Prostanoid (TP) Receptor Antagonists as Prototype Therapeutics for Alzheimer’s Disease

Soper, James H., Sugiyama, Shimpei, Herbst-Robinson, Katie, James, Michael J., Wang, Xiaozhao, Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.

Journal:

ACS Chemical Neuroscience

Year:

2012

Language:

english

File:

PDF, 2.22 MB

english, 2012

31

Lysosomal Delivery of the Major Myelin Glycoprotein in the Absence of Myelin Assembly: Posttranslational Regulation of the Level of Expression by Schwann Cells

Kurt R. Brunden and Joseph F. Poduslo

Journal:

The Journal of Cell Biology

Year:

1987

Language:

english

File:

PDF, 2.75 MB

english, 1987

32

Myelin protein expression in dissociated superior cervical ganglia and dorsal root ganglia cultures

Kurt R. Brunden, Y. Ding, B. S. Hennington

Journal:

Journal of Neuroscience Research

Year:

1992

Language:

english

File:

PDF, 975 KB

english, 1992

33

Age-Dependent Changes in the Oligosaccharide Structure of the Major Myelin Glycoprotein, P0

Kurt R. Brunden

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 1.17 MB

english, 1992

34

Catabolic Regulation of the Expression of the Major Myelin Glycoprotein by Schwann Cells in Culture

Kurt R. Brunden, Anthony J. Windebank, Joseph F. Poduslo

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 1.67 MB

english, 1990

35

Characterization of multiple forms of the human glycine transporter type-2

Michael J Gallagher, Loyd H Burgess, Kurt R Brunden

Journal:

Molecular Brain Research

Year:

1999

Language:

english

File:

PDF, 918 KB

english, 1999

36

A Phorbol Ester-Sensitive Kinase Catalyzes the Phosphorylation of P0 Glycoprotein in Myelin

Kurt R. Brunden, Joseph F. Poduslo

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 1.63 MB

english, 1987

37

Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties

Carlo Ballatore, Alex Crowe, Francesco Piscitelli, Michael James, Kevin Lou, Gabrielle Rossidivito, Yuemang Yao, John Q. Trojanowski, Virginia M.-Y. Lee, Kurt R. Brunden, Amos B. Smith III

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 584 KB

english, 2012

38

IgM/IgG solid-phase antibody-capture assay with biotin/125I-streptavidin amplification: application to normal human sural nerve biopsies

Joseph F. Poduslo, Geoffry L. Curran, Kurt R. Brunden, Peter J. Dyck

Journal:

Journal of Neuroimmunology

Year:

1988

Language:

english

File:

PDF, 411 KB

english, 1988

39

Inhibition of complement alternative pathway function with anti-properdin monoclonal antibodies

Rekha Gupta-Bansal, J.Brian Parent, Kurt R Brunden

Journal:

Molecular Immunology

Year:

2000

Language:

english

File:

PDF, 306 KB

english, 2000

40

Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists

Ballatore, Carlo, Soper, James H., Piscitelli, Francesco, James, Michael, Huang, Longchuan, Atasoylu, Onur, Huryn, Donna M., Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R., Smith, Amos B.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.38 MB

english, 2011

41

Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4- e ]pyrrolo[3,4- g ]indolizine-4,6(1 H ,5 H )-diones as New Glycogen Synthase Kinase-3β Inhibitors

La Pietra, Valeria, La Regina, Giuseppe, Coluccia, Antonio, Famiglini, Valeria, Pelliccia, Sveva, Plotkin, Batya, Eldar-Finkelman, Hagit, Brancale, Andrea, Ballatore, Carlo, Crowe, Alex, Brunden, Kurt

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1023 KB

english, 2013

42

Acidic pH Requirement for Insertion of Colicin E1 into Artificial Membrane Vesicles: Relevance to the Mechanism of Action of Colicins and Certain Toxins

Victor L. Davidson, Kurt R. Brunden and William A. Cramer

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.24 MB

english, 1985

43

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

L. Nathan Tumey, David Bom, Bayard Huck, Elizabeth Gleason, Jianmin Wang, Daniel Silver, Kurt Brunden, Sherry Boozer, Stephen Rundlett, Bruce Sherf, Steven Murphy, Tom Dent, Christina Leventhal, Andre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

44

Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies

Lou, Kevin, Yao, Yuemang, Hoye, Adam T., James, Michael J., Cornec, Anne-Sophie, Hyde, Edward, Gay, Bryant, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Brunden, Kurt R., Ballatore, Carl

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

45

Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors

Herbst-Robinson, Katie J., Liu, Li, James, Michael, Yao, Yuemang, Xie, Sharon X., Brunden, Kurt R.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.53 MB

english, 2016

46

Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis

Monti, Ludovica, Wang, Steven C, Oukoloff, Killian, Smith, Amos B, Brunden, Kurt R, Caffrey, Conor, Ballatore, Carlo

Journal:

Year:

2018

Language:

english

File:

PDF, 1.69 MB

english, 2018

47

Role of basal lamina in Schwann cell glycolipid biosynthesis

Kurt R. Brunden, Rosilyn Gregory, Jun E. Yoshino, Jeffrey K. Yao

Journal:

Neurochemical Research

Year:

1994

Language:

english

File:

PDF, 790 KB

english, 1994

48

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

Makani, Vishruti, Zhang, Bin, Han, Heeoon, Yao, Yuemang, Lassalas, Pierrik, Lou, Kevin, Paterson, Ian, Lee, Virginia M. Y., Trojanowski, John Q., Ballatore, Carlo, Smith, Amos B., Brunden, Kurt R.

Journal:

Acta Neuropathologica Communications

Year:

2016

Language:

english

File:

PDF, 2.14 MB

english, 2016

49

Discovery of Brain-Penetrant, Orally Bioavailable Aminothienopyridazine Inhibitors of Tau Aggregation

Yao, Yuemang, Hyde, Edward, Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B., Ballatore, Carlo, Brunden, Kurt R., Piscitelli, Francesco, James, Michael J., Crowe, Alex

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 998 KB

english, 2010

50

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimerâs disease

Gibbons, Garrett S., Kim, Soo-Jung, Wu, Qihui, Riddle, Dawn M., Leight, Susan N., Changolkar, Lakshmi, Xu, Hong, Meymand, Emily S., OâReilly, Mia, Zhang, Bin, Brunden, Kurt R., Trojanowski, John Q.,

Journal:

Molecular Neurodegeneration

Year:

2020

File:

PDF, 5.21 MB

2020

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